The article highlights the severe impact of polio in the Arab world, especially amid ongoing conflicts and crises that weaken health systems and hinder vaccination efforts. Children under five are most at risk, with recent outbreaks in Gaza, Syria, Yemen, and Iraq illustrating the vulnerability caused by political instability, insecurity, and disrupted healthcare. The failure of global initiatives like GPEI in crisis zones is exacerbated by violence and targeted attacks on health services. Cross-border displacement further risks spreading poliovirus regionally and globally, threatening future generations. Addressing these challenges requires context-specific strategies, community-led vaccination campaigns, and strong diplomatic efforts, including vaccine diplomacy, to ensure effective immunisation and protect children's health in conflict settings.